Therapeutic Targets Database
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TTD Drug ID: DNC003553

Drug Information
NameSEROTONIN
SynonymsSEROTONIN
IndicationNot AvailableExperimental    
Structure

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InChI1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,
3-4,11H2
InChIKeyQZAYGJVTTNCVMB-UHFFFAOYSA-N
Canonical SMILESC1=CC2=C(C=C1O)C(=CN2)CCN    
TargetAdenosine A3 receptorInhibitor[1]
Serotonin 1a (5-HT1a) receptorInhibitor[2]
Serotonin 1b (5-HT1b) receptorInhibitor[3]
Serotonin 1d (5-HT1d) receptorInhibitor[4]
Serotonin 2a (5-HT2a) receptorInhibitor[2]
Serotonin 2b (5-HT2b) receptorInhibitor[5]
Serotonin 2c (5-HT2c) receptorInhibitor[6]
Serotonin 3a (5-HT3a) receptorInhibitor[7]
Serotonin 3b (5-HT3b) receptorInhibitor[7]
Serotonin 4 (5-HT4) receptorInhibitor[6]
Serotonin 5a (5-HT5a) receptorInhibitor[8]
Serotonin 6 (5-HT6) receptorInhibitor[9]
Serotonin 7 (5-HT7) receptorInhibitor[8]
Ref 1J Med Chem. 2005 Nov 3;48(22):6887-96.2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. To Reference
Ref 2J Med Chem. 2009 Nov 12;52(21):6946-50.Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization. To Reference
Ref 3J Med Chem. 2008 Nov 27;51(22):7094-8.cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia. To Reference
Ref 4J Med Chem. 2008 Jun 26;51(12):3609-16. Epub 2008 May 29.Designing selective, high affinity ligands of 5-HT1D receptor by covalent dimerization of 5-HT1F ligands derived from 4-fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide. To Reference
Ref 5Bioorg Med Chem Lett. 2006 Feb;16(3):677-80. Epub 2005 Oct 27.Pyrrolo(iso)quinoline derivatives as 5-HT(2C) receptor agonists. To Reference
Ref 6J Nat Prod. 2006 Oct;69(10):1421-4.Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands. To Reference
Ref 7J Med Chem. 1999 May 6;42(9):1556-75.Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors. To Reference
Ref 8J Med Chem. 2008 Jul 24;51(14):4150-69. Epub 2008 Jun 28.Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. To Reference
Ref 9J Med Chem. 2010 Mar 25;53(6):2521-7.5-Cyclic amine-3-arylsulfonylindazoles as novel 5-HT6 receptor antagonists. To Reference



 

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