Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DNC003554

Drug Information
NameQUIPAZINE
SynonymsQUIPAZINE
IndicationNot AvailableExperimental    
Structure

Click to save drug structure in 3D MOL format

Click to save drug structure in 2D MOL format
InChI1S/C13H15N3/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16/h1-6,
14H,7-10H2
InChIKeyXRXDAJYKGWNHTQ-UHFFFAOYSA-N
Canonical SMILESC1CN(CCN1)C2=NC3=CC=CC=C3C=C2    
CAS NumberCAS 4774-24-7
TargetSerotonin 1a (5-HT1a) receptorInhibitor[1]
Serotonin 1d (5-HT1d) receptorInhibitor[2]
Serotonin 2a (5-HT2a) receptorInhibitor[1]
Serotonin 3a (5-HT3a) receptorInhibitor[1]
Serotonin 3b (5-HT3b) receptorInhibitor[3]
Serotonin 6 (5-HT6) receptorInhibitor[4]
Serotonin transporterInhibitor[5]
Serotonin transporterInhibitor[5]
Ref 1J Med Chem. 2009 Nov 12;52(21):6946-50.Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization. To Reference
Ref 2J Med Chem. 1986 Nov;29(11):2375-80.5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. To Reference
Ref 3J Med Chem. 1999 May 6;42(9):1556-75.Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors. To Reference
Ref 4J Med Chem. 2003 Jul 3;46(14):2795-812.Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). To Reference
Ref 5Bioorg Med Chem Lett. 2000 Jul 17;10(14):1559-62.Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 1. To Reference



 

Welcome to sign our Guestbook.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhu.


Dr. Chen Yuzong
Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543