Therapeutic Targets Database
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TTD Drug ID: DNC003556

Drug Information
NameCGS-27023A
IndicationNot AvailableExperimental    
Structure

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InChI1S/C18H23N3O5S/c1-13(2)17(18(22)20-23)21(12-14-5-4-10-19-11-14)27
(24,25)16-8-6-15(26-3)7-9-16/h4-11,13,17,23H,12H2,1-3H3,(H,20,22)
/t17-/m1/s1
InChIKeyBSIZUMJRKYHEBR-QGZVFWFLSA-N
Canonical SMILESCC(C)C(C(=O)NO)N(CC1=CN=CC=C1)S(=O)(=O)C2=CC=C(C=C2)OC    
Isomeric SMILESCC(C)[C@H](C(=O)NO)N(CC1=CN=CC=C1)S(=O)(=O)C2=CC=C(C=C2)OC
TargetADAMTS4Inhibitor[1]
Anthrax lethal factorInhibitor[2]
Carbonic anhydrase IIInhibitor[3]
Carbonic anhydrase IXInhibitor[3]
Matrix metalloproteinase 13Inhibitor[4]
Matrix metalloproteinase 14Inhibitor[5]
Matrix metalloproteinase 3Inhibitor[6]
Matrix metalloproteinase 7Inhibitor[5]
Matrix metalloproteinase 8Inhibitor[7]
Matrix metalloproteinase 9Inhibitor[8]
Matrix metalloproteinase-1Inhibitor[2]
Matrix metalloproteinase-2Inhibitor[8]
Ref 1Bioorg Med Chem Lett. 2006 Jan 15;16(2):311-6. Epub 2005 Nov 3.Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors. To Reference
Ref 2Bioorg Med Chem Lett. 2006 Feb 15;16(4):964-8. Epub 2005 Dec 9.The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection. To Reference
Ref 3Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. Epub 2007 Jan 19.Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates. To Reference
Ref 4Bioorg Med Chem Lett. 2001 Apr 23;11(8):1009-13.Heterocycle-based MMP inhibitors with P2' substituents. To Reference
Ref 5Bioorg Med Chem. 2007 Feb 1;15(3):1266-74. Epub 2006 Nov 14.Methotrexate gamma-hydroxamate derivatives as potential dual target antitumor drugs. To Reference
Ref 6Bioorg Med Chem Lett. 2005 Mar 1;15(5):1321-6.N-i-Propoxy-N-biphenylsulfonylaminobutylhydroxamic acids as potent and selective inhibitors of MMP-2 and MT1-MMP. To Reference
Ref 7J Med Chem. 1999 Nov 4;42(22):4547-62.Design, synthesis, and biological evaluation of potent thiazine- and thiazepine-based matrix metalloproteinase inhibitors. To Reference
Ref 8Bioorg Med Chem Lett. 1999 Jun 21;9(12):1691-6.Picking the S1, S1' and S2' pockets of matrix metalloproteinases. A niche for potent acyclic sulfonamide inhibitors. To Reference



 

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