Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DNC003593

Drug Information
NameROLIPRAM
SynonymsROLIPRAM
IndicationNot AvailableExperimental    
Structure

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InChI1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-
2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1
InChIKeyHJORMJIFDVBMOB-LBPRGKRZSA-N
Canonical SMILESCOC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3    
Isomeric SMILESCOC1=C(C=C(C=C1)[C@H]2CC(=O)NC2)OC3CCCC3
CAS NumberCAS 61413-54-5
TargetPhosphodiesterase 4AInhibitor[1]
Phosphodiesterase 4BInhibitor[2]
Phosphodiesterase 4DInhibitor[3]
Phosphodiesterase 5Inhibitor[4]
Ref 1Bioorg. Med. Chem. Lett. 5(17):1965-1968 (1995) To Reference
Ref 2J Med Chem. 1997 May 9;40(10):1417-21.Novel heterocyclic-fused pyridazinones as potent and selective phosphodiesterase IV inhibitors. To Reference
Ref 3Bioorg Med Chem. 2010 Mar 15;18(6):2204-18. Epub 2010 Feb 8.In silico search for multi-target anti-inflammatories in Chinese herbs and formulas. To Reference
Ref 4J Med Chem. 1994 Jun 24;37(13):2106-11.Cyclic GMP phosphodiesterase inhibitors. 2. Requirement of 6-substitution of quinazoline derivatives for potent and selective inhibitory activity. To Reference



 

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