Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DNC003603

Drug Information
IndicationNot AvailableExperimental    

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Canonical SMILESC1=CC=C2C(=C1)C=C(C(=O)N2)C3=CC4=CC=CC=C4N3    
TargetSerine/threonine-protein kinase Chk1 Inhibitor[1]
Vascular endothelial growth factor receptor 2Inhibitor[2]
Ref 1Bioorg Med Chem Lett. 2006 Nov 15;16(22):5907-12. Epub 2006 Sep 20.Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors. To Reference
Ref 2Bioorg Med Chem Lett. 2004 Jan 19;14(2):351-5.Optimization of the indolyl quinolinone class of KDR (VEGFR-2) kinase inhibitors: effects of 5-amido- and 5-sulphonamido-indolyl groups on pharmacokinetics and hERG binding. To Reference


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