Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DNC003635

Drug Information
IndicationNot AvailableExperimental    

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Canonical SMILESC1=CN=CC=C1C2=CN3C(=C(C=N3)C4=CC=NC=C4)N=C2    
TargetVascular endothelial growth factor receptor 1Inhibitor[1]
Vascular endothelial growth factor receptor 2Inhibitor[2]
Vascular endothelial growth factor receptor 3Inhibitor[1]
Ref 1Bioorg Med Chem Lett. 2002 Oct 7;12(19):2767-70.Synthesis and initial SAR studies of 3,6-disubstituted pyrazolo[1,5-a]pyrimidines: a new class of KDR kinase inhibitors. To Reference
Ref 2Bioorg Med Chem Lett. 2002 Dec 16;12(24):3537-41.Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics. To Reference


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