Therapeutic Targets Database
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TTD Drug ID: DNC003714

Drug Information
NameILOMASTAT
SynonymsILOMASTAT
IndicationNot AvailableExperimental    
Structure

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InChI1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)
9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,
(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1
InChIKeyNITYDPDXAAFEIT-DYVFJYSZSA-N
Canonical SMILESCC(C)CC(CC(=O)NO)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC    
Isomeric SMILESCC(C)C[C@H](CC(=O)NO)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)NC
TargetMatrix metalloproteinase 12Inhibitor[1]
Matrix metalloproteinase 13Inhibitor[2]
Matrix metalloproteinase 14Inhibitor[3]
Matrix metalloproteinase 26Inhibitor[1]
Matrix metalloproteinase 3Inhibitor[3]
Matrix metalloproteinase 8Inhibitor[4]
Matrix metalloproteinase 9Inhibitor[3]
Matrix metalloproteinase-1Inhibitor[3]
Matrix metalloproteinase-2Inhibitor[3]
Ref 1J Med Chem. 2006 Jan 26;49(2):456-8.Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids. To Reference
Ref 2J Biol Chem. 2007 Sep 21;282(38):27781-91. Epub 2007 Jul 10.Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects. To Reference
Ref 3Bioorg Med Chem. 2008 Sep 15;16(18):8745-59. Epub 2008 Jul 20.Introduction of the 4-(4-bromophenyl)benzenesulfonyl group to hydrazide analogs of Ilomastat leads to potent gelatinase B (MMP-9) inhibitors with improved selectivity. To Reference
Ref 4Bioorg. Med. Chem. Lett. 5(4):349-352 (1995) To Reference



 

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