Therapeutic Targets Database
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TTD Drug ID: DNC003717

Drug Information
NameSC-44463
IndicationNot AvailableExperimental    
Structure

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InChI1S/C19H29N3O5/c1-12(2)9-14(11-17(23)22-26)18(24)21-16(19(25)20-3)
10-13-5-7-15(27-4)8-6-13/h5-8,12,14,16,26H,9-11H2,1-4H3,(H,20,25)
(H,21,24)(H,22,23)/t14-,16+/m1/s1
InChIKeyQYZPDCGWIJYZMN-ZBFHGGJFSA-N
Canonical SMILESCC(C)CC(CC(=O)NO)C(=O)NC(CC1=CC=C(C=C1)OC)C(=O)NC    
Isomeric SMILESCC(C)C[C@H](CC(=O)NO)C(=O)N[C@@H](CC1=CC=C(C=C1)OC)C(=O)NC
TargetADAMTS4Inhibitor[1]
ADAMTS5Inhibitor[1]
Matrix metalloproteinase 3Inhibitor[2]
Matrix metalloproteinase 7Inhibitor[3]
Matrix metalloproteinase 8Inhibitor[1]
Matrix metalloproteinase 9Inhibitor[1]
Matrix metalloproteinase-1Inhibitor[3]
Matrix metalloproteinase-2Inhibitor[3]
Ref 1J Med Chem. 2001 Oct 11;44(21):3347-50.Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors. To Reference
Ref 2Bioorg. Med. Chem. Lett. 7(18):2331-2336 (1997) To Reference
Ref 3J Med Chem. 2003 Jul 31;46(16):3514-25.A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers. To Reference



 

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