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TTD Drug ID:
DNC003717
Drug
Information |
Name | SC-44463 | Indication | Not Available | Experimental | Structure |
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| InChI | 1S/C19H29N3O5/c1-12(2)9-14(11-17(23)22-26)18(24)21-16(19(25)20-3) 10-13-5-7-15(27-4)8-6-13/h5-8,12,14,16,26H,9-11H2,1-4H3,(H,20,25) (H,21,24)(H,22,23)/t14-,16+/m1/s1 | InChIKey | QYZPDCGWIJYZMN-ZBFHGGJFSA-N | Canonical SMILES | CC(C)CC(CC(=O)NO)C(=O)NC(CC1=CC=C(C=C1)OC)C(=O)NC | Isomeric SMILES | CC(C)C[C@H](CC(=O)NO)C(=O)N[C@@H](CC1=CC=C(C=C1)OC)C(=O)NC | Target | ADAMTS4 |  | Inhibitor | [1] | ADAMTS5 |  | Inhibitor | [1] | Matrix metalloproteinase 3 |  | Inhibitor | [2] | Matrix metalloproteinase 7 |  | Inhibitor | [3] | Matrix metalloproteinase 8 |  | Inhibitor | [1] | Matrix metalloproteinase 9 |  | Inhibitor | [1] | Matrix metalloproteinase-1 |  | Inhibitor | [3] | Matrix metalloproteinase-2 |  | Inhibitor | [3] | Ref 1 | J Med Chem. 2001 Oct 11;44(21):3347-50.Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors. To Reference | Ref 2 | Bioorg. Med. Chem. Lett. 7(18):2331-2336 (1997) To Reference | Ref 3 | J Med Chem. 2003 Jul 31;46(16):3514-25.A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers. To Reference |
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