Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DNC003726

Drug Information
IndicationNot AvailableExperimental    

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Canonical SMILESCS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F    
TargetArachidonate 5-lipoxygenaseInhibitor[1]
Cytochrome P450 2D6Inhibitor[2]
Cytochrome P450 3A4Inhibitor[2]
Glycogen synthase kinase-3 betaInhibitor[3]
MAP kinase p38 alphaInhibitor[4]
MAP kinase p38 betaInhibitor[5]
MAP kinase p38 gammaInhibitor[3]
Mitogen-activated protein kinase 1Inhibitor[6]
Protein kinase C alpha Inhibitor[3]
Rho-associated protein kinase 2Inhibitor[3]
Ribosomal protein S6 kinase alpha 5Inhibitor[3]
Serine/threonine-protein kinase AKTInhibitor[3]
Serine/threonine-protein kinase Chk1 Inhibitor[3]
Serine/threonine-protein kinase RAFInhibitor[5]
Serine/threonine-protein kinase RIPK2Inhibitor[7]
Serine/threonine-protein kinase Sgk1Inhibitor[3]
Tyrosine-protein kinase LCKInhibitor[5]
Tyrosine-protein kinase SRCInhibitor[7]
c-Jun N-terminal kinase 1Inhibitor[3]
c-Jun N-terminal kinase 2Inhibitor[7]
c-Jun N-terminal kinase 3Inhibitor[5]
Ref 1Bioorg. Med. Chem. Lett. 5(11):1171-1176 (1995) To Reference
Ref 2J Med Chem. 2004 Dec 2;47(25):6311-25.Tetrasubstituted imidazole inhibitors of cytokine release: probing substituents in the N-1 position. To Reference
Ref 3Biochem J. 2000 Oct 1;351(Pt 1):95-105.Specificity and mechanism of action of some commonly used protein kinase inhibitors. To Reference
Ref 4Bioorg Med Chem. 2010 Mar 15;18(6):2204-18. Epub 2010 Feb 8.In silico search for multi-target anti-inflammatories in Chinese herbs and formulas. To Reference
Ref 5J Med Chem. 2008 Jul 24;51(14):4122-49. Epub 2008 Jun 26.Design, synthesis, and biological evaluation of novel Tri- and tetrasubstituted imidazoles as highly potent and specific ATP-mimetic inhibitors of p38 MAP kinase: focus on optimized interactions with the enzyme's surface-exposed front region. To Reference
Ref 6Antimicrob Agents Chemother. 2007 Dec;51(12):4324-8. Epub 2007 Oct 8.Drugs designed to inhibit human p38 mitogen-activated protein kinase activation treat Toxoplasma gondii and Encephalitozoon cuniculi infection. To Reference
Ref 7J Med Chem. 2005 Jun 16;48(12):4138-52.Rapid computational identification of the targets of protein kinase inhibitors. To Reference
Ref 8J Med Chem. 2005 Jan 27;48(2):414-26.Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation. To Reference


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