Therapeutic Targets Database
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TTD Drug ID: DNC003727

Drug Information
NameONAPRISTONE
SynonymsONAPRISTONE
IndicationNot AvailableExperimental    
Structure

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InChI1S/C29H39NO3/c1-28-18-25(19-5-8-21(9-6-19)30(2)3)27-23-12-10-22(3
2)17-20(23)7-11-24(27)26(28)13-15-29(28,33)14-4-16-31/h5-6,8-9,17
,24-26,31,33H,4,7,10-16,18H2,1-3H3/t24-,25+,26-,28+,29+/m0/s1
InChIKeyIEXUMDBQLIVNHZ-YOUGDJEHSA-N
Canonical SMILESCC12CC(C3=C4CCC(=O)C=C4CCC3C1CCC2(CCCO)O)C5=CC=C(C=C5)N(C)C    
Isomeric SMILESC[C@@]12C[C@@H](C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@@]2(CCCO)O)C5=CC=C
(C=C5)N(C)C
TargetAndrogen ReceptorInhibitor[1]
Estrogen receptor alphaInhibitor[2]
Estrogen receptor betaInhibitor[2]
Glucocorticoid receptorInhibitor[1]
Mineralocorticoid receptorInhibitor[1]
Progesterone receptorInhibitor[3]
Ref 1Bioorg Med Chem Lett. 2003 Jun 16;13(12):2075-8.Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore. To Reference
Ref 2J Med Chem. 1996 Apr 26;39(9):1778-89.Synthesis and biological activity of novel nonsteroidal progesterone receptor antagonists based on cyclocymopol monomethyl ether. To Reference
Ref 3J Med Chem. 1998 Aug 27;41(18):3461-6.Discovery and preliminary SAR studies of a novel, nonsteroidal progesterone receptor antagonist pharmacophore. To Reference



 

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