Therapeutic Targets Database
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TTD Drug ID: DNC003728

Drug Information
NameIK-682
IndicationNot AvailableExperimental    
Structure

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InChI1S/C25H27N3O4/c1-16-14-18(21-6-4-5-7-22(21)26-16)15-32-20-10-8-19
(9-11-20)25(3)12-13-28(24(25)30)17(2)23(29)27-31/h4-11,14,17,31H,
12-13,15H2,1-3H3,(H,27,29)/t17-,25+/m1/s1
InChIKeyYDMIPBHQKFOFQW-NSYGIPOTSA-N
Canonical SMILESCC1=NC2=CC=CC=C2C(=C1)COC3=CC=C(C=C3)C4(CCN(C4=O)C(C)C(=O)NO)C    
Isomeric SMILESCC1=NC2=CC=CC=C2C(=C1)COC3=CC=C(C=C3)[C@@]4(CCN(C4=O)[C@H](C)C(=O)NO)C
TargetADAM17Inhibitor[1]
Matrix metalloproteinase 13Inhibitor[2]
Matrix metalloproteinase 14Inhibitor[2]
Matrix metalloproteinase 16Inhibitor[2]
Matrix metalloproteinase 3Inhibitor[2]
Matrix metalloproteinase 7Inhibitor[2]
Matrix metalloproteinase 8Inhibitor[2]
Matrix metalloproteinase 9Inhibitor[2]
Matrix metalloproteinase-2Inhibitor[2]
TNF-alphaInhibitor[2]
Ref 1Bioorg Med Chem. 2008 Oct 1;16(19):8781-94. Epub 2008 Aug 29.Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. To Reference
Ref 2J Med Chem. 2002 Nov 7;45(23):4954-7.Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. To Reference



 

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