Therapeutic Targets Database
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TTD Drug ID: DNC003791

Drug Information
NamePD-98059
IndicationNot AvailableExperimental    
Structure

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InChI1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(
10)20-15/h2-9H,17H2,1H3
InChIKeyQFWCYNPOPKQOKV-UHFFFAOYSA-N
Canonical SMILESCOC1=CC=CC(=C1N)C2=CC(=O)C3=CC=CC=C3O2    
TargetDual specificity mitogen-activated protein kinase kinase 1Inhibitor[1]
Glycogen synthase kinase-3 betaInhibitor[2]
MAP kinase ERK2Inhibitor[2]
MAP kinase p38 alphaInhibitor[2]
MAP kinase p38 betaInhibitor[2]
MAP kinase p38 gammaInhibitor[2]
Protein kinase C alpha Inhibitor[2]
Rho-associated protein kinase 2Inhibitor[2]
Ribosomal protein S6 kinase alpha 5Inhibitor[2]
Serine/threonine-protein kinase AKTInhibitor[2]
Serine/threonine-protein kinase Chk1 Inhibitor[2]
Serine/threonine-protein kinase RAFInhibitor[1]
Serine/threonine-protein kinase Sgk1Inhibitor[2]
Tyrosine-protein kinase LCKInhibitor[2]
c-Jun N-terminal kinase 1Inhibitor[2]
Ref 1J Med Chem. 2002 Jan 17;45(2):529-32.Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). To Reference
Ref 2Biochem J. 2000 Oct 1;351(Pt 1):95-105.Specificity and mechanism of action of some commonly used protein kinase inhibitors. To Reference



 

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