Therapeutic Targets Database
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TTD Drug ID: DNC003853

Drug Information
NameAMENTOFLAVONE
SynonymsAMENTOFLAVONE
IndicationNot AvailableExperimental    
Structure

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InChI1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)2
7(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9
-26(28)39-25/h1-12,31-36H
InChIKeyYUSWMAULDXZHPY-UHFFFAOYSA-N
Canonical SMILESC1=CC(=CC=C1C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)C4=C(C=CC(=C4)C5=CC(=O)C6=C(C=
C(C=C6O5)O)O)O)O    
TargetGABA receptor alpha-1 subunitInhibitor[1]
GABA receptor alpha-2 subunitInhibitor[1]
GABA receptor alpha-3 subunitInhibitor[1]
GABA receptor alpha-5 subunitInhibitor[1]
GABA receptor beta-2 subunitInhibitor[1]
GABA receptor gamma-2 subunitInhibitor[1]
GABA receptor rho-3 subunitInhibitor[1]
Induced myeloid leukemia cell differentiation protein Mcl-1Inhibitor[2]
Xanthine dehydrogenaseInhibitor[3]
Ref 1Bioorg Med Chem Lett. 2003 Jul 21;13(14):2281-4.Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors. To Reference
Ref 2Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). To Reference
Ref 3J. Nat. Prod. 51(2):345-348 (1988) To Reference



 

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