Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DNC003860

Drug Information
NamePKF-242-484;TNF-484
IndicationNot AvailableExperimental    
Structure

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InChI1S/C19H29N3O6/c1-19(2,3)15(18(26)20-4)21-17(25)14(13(10-23)16(24)
22-27)11-6-8-12(28-5)9-7-11/h6-9,13-15,23,27H,10H2,1-5H3,(H,20,26
)(H,21,25)(H,22,24)/t13-,14+,15+/m0/s1
InChIKeyIOLRUMINDIUCLJ-RRFJBIMHSA-N
Canonical SMILESCC(C)(C)C(C(=O)NC)NC(=O)C(C1=CC=C(C=C1)OC)C(CO)C(=O)NO    
Isomeric SMILESCC(C)(C)[C@@H](C(=O)NC)NC(=O)[C@H](C1=CC=C(C=C1)OC)[C@H](CO)C(=O)NO
TargetADAM17Inhibitor[1]
Matrix metalloproteinase 13Inhibitor[2]
Matrix metalloproteinase 3Inhibitor[2]
Matrix metalloproteinase-1Inhibitor[2]
TNF-alphaInhibitor[3]
Ref 1Bioorg Med Chem. 2009 Jan 15;17(2):444-59. Epub 2008 Dec 3.Current perspective of TACE inhibitors: a review. To Reference
Ref 2Bioorg Med Chem Lett. 2006 May 15;16(10):2632-6. Epub 2006 Mar 3.A cassette-dosing approach for improvement of oral bioavailability of dual TACE/MMP inhibitors. To Reference
Ref 3J Med Chem. 2002 May 23;45(11):2289-93.Beta-aryl-succinic acid hydroxamates as dual inhibitors of matrix metalloproteinases and tumor necrosis factor alpha converting enzyme. To Reference



 

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