Therapeutic Targets Database
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TTD Drug ID: DNC003910

Drug Information
NameN6-CYCLOPENTYLADENOSINE
SynonymsN6-CYCLOPENTYLADENOSINE
IndicationNot AvailableExperimental    
Structure

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InChI1S/C15H21N5O4/c21-5-9-11(22)12(23)15(24-9)20-7-18-10-13(16-6-17-1
4(10)20)19-8-3-1-2-4-8/h6-9,11-12,15,21-23H,1-5H2,(H,16,17,19)/t9
-,11-,12-,15-/m1/s1
InChIKeySQMWSBKSHWARHU-SDBHATRESA-N
Canonical SMILESC1CCC(C1)NC2=NC=NC3=C2N=CN3C4C(C(C(O4)CO)O)O    
Isomeric SMILESC1CCC(C1)NC2=NC=NC3=C2N=CN3[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O
TargetA1 adenosine receptorInhibitor[1]
Adenosine A2a receptorInhibitor[2]
Adenosine A2b receptorInhibitor[3]
Adenosine A3 receptorInhibitor[4]
Adenylate cyclase type IIInhibitor[5]
Equilibrative nucleoside transporter 1Inhibitor[6]
Ref 1Bioorg Med Chem. 2008 Jan 1;16(1):336-53. Epub 2007 Sep 22.5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species. To Reference
Ref 2Bioorg Med Chem. 2010 Mar 15;18(6):2195-203. Epub 2010 Feb 4.2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. To Reference
Ref 3J Med Chem. 1988 Jun;31(6):1179-83.Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives. To Reference
Ref 4J Med Chem. 2005 Dec 29;48(26):8103-7.Semi-rational design of (north)-methanocarba nucleosides as dual acting A(1) and A(3) adenosine receptor agonists: novel prototypes for cardioprotection. To Reference
Ref 5J Med Chem. 1991 Dec;34(12):3388-90.Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors. To Reference
Ref 6J Med Chem. 2005 Jan 13;48(1):321-9.Inhibition of nucleoside transport proteins by C8-alkylamine-substituted purines. To Reference



 

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