Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DNC004280

Drug Information
IndicationNot AvailableExperimental    

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Canonical SMILESC1=CC(=O)C=CC1=C2NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F    
TargetArachidonate 5-lipoxygenaseInhibitor[1]
Glycogen synthase kinase-3 betaInhibitor[2]
MAP kinase ERK2Inhibitor[2]
MAP kinase p38 alphaInhibitor[2]
MAP kinase p38 betaInhibitor[2]
MAP kinase p38 gammaInhibitor[2]
Protein kinase C alpha Inhibitor[2]
Rho-associated protein kinase 2Inhibitor[2]
Ribosomal protein S6 kinase alpha 5Inhibitor[2]
Serine/threonine-protein kinase AKTInhibitor[2]
Serine/threonine-protein kinase Chk1 Inhibitor[2]
Serine/threonine-protein kinase Sgk1Inhibitor[2]
Tyrosine-protein kinase LCKInhibitor[3]
c-Jun N-terminal kinase 1Inhibitor[2]
Ref 1Bioorg. Med. Chem. Lett. 5(11):1171-1176 (1995) To Reference
Ref 2Biochem J. 2000 Oct 1;351(Pt 1):95-105.Specificity and mechanism of action of some commonly used protein kinase inhibitors. To Reference
Ref 3J Med Chem. 2008 Jul 24;51(14):4122-49. Epub 2008 Jun 26.Design, synthesis, and biological evaluation of novel Tri- and tetrasubstituted imidazoles as highly potent and specific ATP-mimetic inhibitors of p38 MAP kinase: focus on optimized interactions with the enzyme's surface-exposed front region. To Reference


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