Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DNC004280

Drug Information
NameSB-202190
SynonymsSB-202190
IndicationNot AvailableExperimental    
Structure

Click to save drug structure in 3D MOL format

Click to save drug structure in 2D MOL format
InChI1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-2
0(23-18)15-3-7-17(25)8-4-15/h1-12,23-24H
InChIKeyNJNKPVPFGLGHPA-UHFFFAOYSA-N
Canonical SMILESC1=CC(=O)C=CC1=C2NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F    
TargetArachidonate 5-lipoxygenaseInhibitor[1]
Glycogen synthase kinase-3 betaInhibitor[2]
MAP kinase ERK2Inhibitor[2]
MAP kinase p38 alphaInhibitor[2]
MAP kinase p38 betaInhibitor[2]
MAP kinase p38 gammaInhibitor[2]
Protein kinase C alpha Inhibitor[2]
Rho-associated protein kinase 2Inhibitor[2]
Ribosomal protein S6 kinase alpha 5Inhibitor[2]
Serine/threonine-protein kinase AKTInhibitor[2]
Serine/threonine-protein kinase Chk1 Inhibitor[2]
Serine/threonine-protein kinase Sgk1Inhibitor[2]
Tyrosine-protein kinase LCKInhibitor[3]
c-Jun N-terminal kinase 1Inhibitor[2]
Ref 1Bioorg. Med. Chem. Lett. 5(11):1171-1176 (1995) To Reference
Ref 2Biochem J. 2000 Oct 1;351(Pt 1):95-105.Specificity and mechanism of action of some commonly used protein kinase inhibitors. To Reference
Ref 3J Med Chem. 2008 Jul 24;51(14):4122-49. Epub 2008 Jun 26.Design, synthesis, and biological evaluation of novel Tri- and tetrasubstituted imidazoles as highly potent and specific ATP-mimetic inhibitors of p38 MAP kinase: focus on optimized interactions with the enzyme's surface-exposed front region. To Reference



 

Welcome to sign our Guestbook.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhu.


Dr. Chen Yuzong
Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543