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TTD Drug ID:
DNC004381
Drug
Information |
Name | A-420983 | Indication | Not Available | Experimental | Structure |
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| InChI | 1S/C33H39N9O2/c1-39-14-16-41(17-15-39)23-9-11-24(12-10-23)42-32-2 9(31(34)35-20-36-32)30(38-42)22-8-13-25(28(19-22)44-3)37-33(43)27 -18-21-6-4-5-7-26(21)40(27)2/h4-8,13,18-20,23-24H,9-12,14-17H2,1- 3H3,(H,37,43)(H2,34,35,36) | InChIKey | STVKLDUINKMZFE-UHFFFAOYSA-N | Canonical SMILES | CN1CCN(CC1)C2CCC(CC2)N3C4=C(C(=N3)C5=CC(=C(C=C5)NC(=O)C6=CC7=CC=CC= C7N6C)OC)C(=NC=N4)N | Target | Tyrosine-protein kinase LCK |  | Inhibitor | [1] | Tyrosine-protein kinase SRC |  | Inhibitor | [1] | Tyrosine-protein kinase TIE-2 |  | Inhibitor | [1] | Ref 1 | Bioorg Med Chem Lett. 2004 May 17;14(10):2613-6.A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection. To Reference |
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