TTD Drug ID: DNC004381

Drug Information
Name	A-420983
Indication	Not Available			Experimental
Structure	Click to save drug structure in 3D MOL format Click to save drug structure in 2D MOL format
InChI	1S/C33H39N9O2/c1-39-14-16-41(17-15-39)23-9-11-24(12-10-23)42-32-2 9(31(34)35-20-36-32)30(38-42)22-8-13-25(28(19-22)44-3)37-33(43)27 -18-21-6-4-5-7-26(21)40(27)2/h4-8,13,18-20,23-24H,9-12,14-17H2,1- 3H3,(H,37,43)(H2,34,35,36)
InChIKey	STVKLDUINKMZFE-UHFFFAOYSA-N
Canonical SMILES	CN1CCN(CC1)C2CCC(CC2)N3C4=C(C(=N3)C5=CC(=C(C=C5)NC(=O)C6=CC7=CC=CC= C7N6C)OC)C(=NC=N4)N
Target	Tyrosine-protein kinase LCK			Inhibitor	[1]
	Tyrosine-protein kinase SRC			Inhibitor	[1]
	Tyrosine-protein kinase TIE-2			Inhibitor	[1]
Ref 1	Bioorg Med Chem Lett. 2004 May 17;14(10):2613-6.A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection. To Reference

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