Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DNC004426

Drug Information
NameN-DESMETHYLCLOZAPINE
SynonymsN-DESMETHYLCLOZAPINE
IndicationNot AvailableExperimental    
Structure

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InChI1S/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3
-1-2-4-14(13)20-15/h1-6,11,19,21H,7-10H2
InChIKeyHESZUPIXRNZIOI-UHFFFAOYSA-N
Canonical SMILESC1CN(CCN1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl    
TargetHERGInhibitor[1]
Muscarinic acetylcholine receptor M2Inhibitor[2]
Muscarinic acetylcholine receptor M3Inhibitor[2]
Muscarinic acetylcholine receptor M4Inhibitor[2]
Muscarinic acetylcholine receptor M5Inhibitor[2]
Ref 1J Med Chem. 2009 Jul 23;52(14):4266-76.Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers. To Reference
Ref 2J Med Chem. 2010 Sep 9;53(17):6386-97.Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential. To Reference



 

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