Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DNC004446

Drug Information
IndicationNot AvailableExperimental    

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Canonical SMILESCN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54    
TargetAnthrax lethal factorInhibitor[1]
Cyclin-dependent kinase 1Inhibitor[2]
G2/mitotic-specific cyclin B1Inhibitor[2]
Glycogen synthase kinase-3 betaInhibitor[3]
MAP kinase ERK2Inhibitor[3]
MAP kinase p38 alphaInhibitor[3]
MAP kinase p38 betaInhibitor[3]
MAP kinase p38 gammaInhibitor[3]
Protein kinase C deltaInhibitor[4]
Protein kinase C epsilonInhibitor[4]
Protein kinase C gammaInhibitor[4]
Rho-associated protein kinase 2Inhibitor[3]
Serine/threonine-protein kinase AKTInhibitor[3]
Serine/threonine-protein kinase Chk1 Inhibitor[3]
Serine/threonine-protein kinase Sgk1Inhibitor[3]
Tyrosine-protein kinase LCKInhibitor[3]
c-Jun N-terminal kinase 1Inhibitor[3]
Ref 1Antimicrob Agents Chemother. 2007 Jul;51(7):2403-11. Epub 2007 May 7.Amiodarone and bepridil inhibit anthrax toxin entry into host cells. To Reference
Ref 2Bioorg Med Chem Lett. 1998 May 5;8(9):1019-22.Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure. To Reference
Ref 3Biochem J. 2000 Oct 1;351(Pt 1):95-105.Specificity and mechanism of action of some commonly used protein kinase inhibitors. To Reference
Ref 4J Biol Chem. 2007 Nov 9;282(45):33052-63. Epub 2007 Sep 17.Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits. To Reference


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