Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DNC004532

Drug Information
NameSEMAXINIB
SynonymsSEMAXINIB
IndicationNot AvailableExperimental    
Structure

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InChI1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)1
8/h3-8,16H,1-2H3,(H,17,18)/b12-8-
InChIKeyWUWDLXZGHZSWQZ-WQLSENKSSA-N
Canonical SMILESCC1=CC(=C(N1)C=C2C3=CC=CC=C3NC2=O)C    
Isomeric SMILESCC1=CC(=C(N1)/C=C\2/C3=CC=CC=C3NC2=O)C
TargetFibroblast growth factor receptor 1Inhibitor[1]
Platelet-derived growth factor receptor alpha Inhibitor[2]
Platelet-derived growth factor receptor betaInhibitor[2]
Stem cell growth factor receptorInhibitor[3]
Tyrosine-protein kinase receptor RETInhibitor[4]
Vascular endothelial growth factor receptor 1Inhibitor[3]
Vascular endothelial growth factor receptor 1Inhibitor[1]
Vascular endothelial growth factor receptor 2Inhibitor[1]
Ref 1J Med Chem. 2002 Dec 19;45(26):5687-93.Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors. To Reference
Ref 2J Med Chem. 2003 Mar 27;46(7):1116-9.Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase. To Reference
Ref 3J Med Chem. 2000 Jun 15;43(12):2310-23.New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis. To Reference
Ref 4Bioorg Med Chem. 2010 Feb 15;18(4):1482-96. Epub 2010 Jan 11.Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors. To Reference



 

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