Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DNC004900

Drug Information
Name4-(2-Hydroxy-ethyl)-benzenesulfonamide
4-(2-hydroxyethyl)benzenesulfonamide
IndicationNot AvailableExperimental    
Structure

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InChI1S/C8H11NO3S/c9-13(11,12)8-3-1-7(2-4-8)5-6-10/h1-4,10H,5-6H2,(H2,
9,11,12)
InChIKeyRYKHXKKLCRPAJP-UHFFFAOYSA-N
Canonical SMILESC1=CC(=CC=C1CCO)S(=O)(=O)N    
TargetCarbonic anhydrase 15Inhibitor[1]
Carbonic anhydrase IIInhibitor[2]
Carbonic anhydrase IXInhibitor[1]
Carbonic anhydrase VIInhibitor[1]
Carbonic anhydrase XIIInhibitor[3]
Carbonic anhydrase XIVInhibitor[4]
Ref 1J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. To Reference
Ref 2Bioorg Med Chem. 2010 Aug 1;18(15):5498-503. Epub 2010 Jun 22.Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors. To Reference
Ref 3Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9.Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs? To Reference
Ref 4Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33.Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. To Reference



 

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