Therapeutic Targets Database
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TTD Drug ID: DNC004953

Drug Information
NameATC-0175
IndicationNot AvailableExperimental    
Structure

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InChI1S/C23H25F2N5O.ClH/c1-30(2)21-17-5-3-4-6-20(17)28-23(29-21)27-16-
10-8-15(9-11-16)26-22(31)14-7-12-18(24)19(25)13-14;/h3-7,12-13,15
-16H,8-11H2,1-2H3,(H,26,31)(H,27,28,29);1H
InChIKeyHUUPKFUYSQNNLO-UHFFFAOYSA-N
Canonical SMILESCN(C)C1=NC(=NC2=CC=CC=C21)NC3CCC(CC3)NC(=O)C4=CC(=C(C=C4)F)F.Cl    
TargetAlpha-1a adrenergic receptorInhibitor[1]
Alpha-2a adrenergic receptorInhibitor[1]
Histamine H1 receptorInhibitor[1]
Melanin-concentrating hormone receptor 1Inhibitor[1]
Neuropeptide Y receptor type 5Inhibitor[2]
Serotonin 1a (5-HT1a) receptorInhibitor[1]
Serotonin 2b (5-HT2b) receptorInhibitor[1]
Ref 1Bioorg Med Chem Lett. 2009 Nov 1;19(21):6166-71. Epub 2009 Sep 6.Pyrimidine-based antagonists of h-MCH-R1 derived from ATC0175: in vitro profiling and in vivo evaluation. To Reference
Ref 2Bioorg Med Chem Lett. 2005 Sep 1;15(17):3853-6.Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1. To Reference



 

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