Therapeutic Targets Database
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TTD Drug ID: DNC005005

Drug Information
NameU-0126
IndicationNot AvailableExperimental    
Structure

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InChI1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(2
4)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+
InChIKeyDVEXZJFMOKTQEZ-JYFOCSDGSA-N
Canonical SMILESC1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N    
Isomeric SMILESC1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\N)/C#N)\C#N)/N
TargetDual specificity mitogen-activated protein kinase kinase 1Inhibitor[1]
Dual specificity mitogen-activated protein kinase kinase 2Inhibitor[1]
Dual specificity mitogen-activated protein kinase kinase 3Inhibitor[2]
Dual specificity mitogen-activated protein kinase kinase 7Inhibitor[2]
Glycogen synthase kinase-3 betaInhibitor[2]
MAP kinase ERK2Inhibitor[2]
MAP kinase p38 alphaInhibitor[2]
MAP kinase p38 betaInhibitor[2]
MAP kinase p38 gammaInhibitor[2]
Protein kinase C alpha Inhibitor[2]
Rho-associated protein kinase 2Inhibitor[2]
Ribosomal protein S6 kinase alpha 5Inhibitor[2]
Serine/threonine-protein kinase AKTInhibitor[2]
Serine/threonine-protein kinase Chk1 Inhibitor[2]
Serine/threonine-protein kinase RAFInhibitor[3]
Serine/threonine-protein kinase Sgk1Inhibitor[2]
Tyrosine-protein kinase LCKInhibitor[2]
c-Jun N-terminal kinase 1Inhibitor[2]
Ref 1Bioorg Med Chem. 2010 Nov 15;18(22):8054-60. Epub 2010 Oct 19.Structure-activity relationships of benzimidazole-based selective inhibitors of the mitogen activated kinase-5 signaling pathway. To Reference
Ref 2Biochem J. 2000 Oct 1;351(Pt 1):95-105.Specificity and mechanism of action of some commonly used protein kinase inhibitors. To Reference
Ref 3Bioorg Med Chem Lett. 2004 Aug 2;14(15):3957-62.Solution phase parallel synthesis and evaluation of MAPK inhibitory activities of close structural analogues of a Ras pathway modulator. To Reference



 

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