Therapeutic Targets Database
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TTD Drug ID: DNC005210

Drug Information
NameNORBINALTORPHIMINE
SynonymsNORBINALTORPHIMINE
IndicationNot AvailableExperimental    
Structure

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InChI1S/C40H43N3O6/c44-25-7-5-21-13-27-39(46)15-23-24-16-40(47)28-14-2
2-6-8-26(45)34-30(22)38(40,10-12-43(28)18-20-3-4-20)36(49-34)32(2
4)41-31(23)35-37(39,29(21)33(25)48-35)9-11-42(27)17-19-1-2-19/h5-
8,19-20,27-28,35-36,41,44-47H,1-4,9-18H2/t27-,28-,35+,36+,37+,38+
,39-,40-/m1/s1
InChIKeyAPSUXPSYBJVPPS-YAUKWVCOSA-N
Canonical SMILESC1CC1CN2CCC34C5C6=C(CC3(C2CC7=C4C(=C(C=C7)O)O5)O)C8=C(N6)C9C12CCN(C(C1
(C8)O)CC1=C2C(=C(C=C1)O)O9)CC1CC1    
Isomeric SMILESC1CC1CN2CC[C@]34[C@@H]5C6=C(C[C@]3([C@H]2CC7=C4C(=C(C=C7)O)O5)O)C8=C(N6)
[C@H]9[C@@]12CCN([C@@H]([C@@]1(C8)O)CC1=C2C(=C(C=C1)O)O9)CC1CC1
CAS NumberCAS 105618-26-6
TargetDelta opioid receptorInhibitor[1]
Kappa opioid receptorInhibitor[2]
Mu opioid receptorInhibitor[2]
Ref 1J Med Chem. 2003 Jul 3;46(14):3127-37.Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a novel potent and selective opioid kappa receptor antagonist. To Reference
Ref 2Bioorg Med Chem Lett. 2010 Sep 1;20(17):5035-8. Epub 2010 Jul 13.Synthesis of pyrrolomorphinan derivatives as kappa opioid agonists. To Reference



 

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