Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DNC005279

Drug Information
NameSB-747651A
IndicationNot AvailableExperimental    
Structure

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InChI1S/C16H22N8O/c1-2-24-14-10(8-20-11-3-5-18-6-4-11)7-19-9-12(14)21-
16(24)13-15(17)23-25-22-13/h7,9,11,18,20H,2-6,8H2,1H3,(H2,17,23)
InChIKeyMBCJUIJWPYUEBX-UHFFFAOYSA-N
Canonical SMILESCCN1C2=C(C=NC=C2CNC3CCNCC3)N=C1C4=NON=C4N    
TargetRho-associated protein kinase 1Inhibitor[1]
Ribosomal protein S6 kinase alpha 5Inhibitor[2]
Serine/threonine-protein kinase AKTInhibitor[1]
Serine/threonine-protein kinase AKT3Inhibitor[1]
Ref 1J Med Chem. 2008 Sep 25;51(18):5663-79.Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. To Reference
Ref 2Bioorg Med Chem Lett. 2005 Jul 15;15(14):3407-11.(1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: further optimisation as highly potent and selective MSK-1-inhibitors. To Reference



 

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National University of Singapore, Singapore


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