Therapeutic Targets Database
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TTD Drug ID: DNC005308

Drug Information
NameREVERSINE
SynonymsREVERSINE
IndicationNot AvailableExperimental    
Structure

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InChI1S/C21H27N7O/c1-2-4-15(5-3-1)24-20-18-19(23-14-22-18)26-21(27-20)
25-16-6-8-17(9-7-16)28-10-12-29-13-11-28/h6-9,14-15H,1-5,10-13H2,
(H3,22,23,24,25,26,27)
InChIKeyZFLJHSQHILSNCM-UHFFFAOYSA-N
Canonical SMILESC1CCC(CC1)NC2=NC(=NC3=C2NC=N3)NC4=CC=C(C=C4)N5CCOCC5    
TargetAdenosine A3 receptorInhibitor[1]
Dual specificity mitogen-activated protein kinase kinase 1Inhibitor[2]
Ref 1J Med Chem. 2005 Jul 28;48(15):4910-8."Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. To Reference
Ref 2Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10482-7. Epub 2007 Jun 12.Reversine increases the plasticity of lineage-committed mammalian cells. To Reference



 

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