Therapeutic Targets Database
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TTD Drug ID: DNC005395

Drug Information
NamePD-173074
IndicationNot AvailableExperimental    
Structure

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InChI1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-
21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h
14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36)
InChIKeyDXCUKNQANPLTEJ-UHFFFAOYSA-N
Canonical SMILESCCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C    
TargetFibroblast growth factor receptor 1Inhibitor[1]
Fibroblast growth factor receptor 2Inhibitor[1]
Fibroblast growth factor receptor 3Inhibitor[1]
Fibroblast growth factor receptor 4Inhibitor[1]
Platelet-derived growth factor receptor alpha Inhibitor[1]
Platelet-derived growth factor receptor betaInhibitor[1]
Vascular endothelial growth factor receptor 1Inhibitor[1]
Vascular endothelial growth factor receptor 2Inhibitor[1]
Vascular endothelial growth factor receptor 3Inhibitor[1]
Ref 1J Med Chem. 2005 Jul 14;48(14):4628-53.Synthesis and structure-activity relationships of soluble 7-substituted 3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-2-amines and related ureas as dual inhibitors of the fibroblast growth factor receptor-1 and vascular endothelial growth factor receptor-2 tyrosine kinases. To Reference



 

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