Therapeutic Targets Database
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TTD Drug ID: DNC005586

Drug Information
Name6-(3-Hydroxy-phenyl)-naphthalen-2-ol
6-(3-hydroxyphenyl)-2-naphthol
6-(3-hydroxyphenyl)naphthalen-2-ol
IndicationNot AvailableExperimental    
Structure

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InChI1S/C16H12O2/c17-15-3-1-2-11(9-15)12-4-5-14-10-16(18)7-6-13(14)8-1
2/h1-10,17-18H
InChIKeyVHWBXEUHUQDHDH-UHFFFAOYSA-N
Canonical SMILESC1=CC(=CC(=C1)O)C2=CC3=C(C=C2)C=C(C=C3)O    
TargetCytochrome P450 3A4Inhibitor[1]
Estradiol 17-beta-dehydrogenase 1Inhibitor[2]
Estrogen receptor alphaInhibitor[3]
Estrogen receptor betaInhibitor[3]
TyrosinaseInhibitor[4]
Ref 1J Med Chem. 2008 Apr 10;51(7):2158-69. Epub 2008 Mar 7.Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases. To Reference
Ref 2J Med Chem. 2008 Aug 14;51(15):4685-98. Epub 2008 Jul 17.Substituted 6-phenyl-2-naphthols. Potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1): design, synthesis, biological evaluation, and pharmacokinetics. To Reference
Ref 3J Med Chem. 2005 Jun 16;48(12):3953-79.ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. To Reference
Ref 4Bioorg Med Chem Lett. 2007 Jan 15;17(2):461-4. Epub 2006 Oct 12.Syntheses of hydroxy substituted 2-phenyl-naphthalenes as inhibitors of tyrosinase. To Reference



 

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