Therapeutic Targets Database
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TTD Drug ID: DNC005781

Drug Information
NameBMS-536924
IndicationNot AvailableExperimental    
Structure

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InChI1S/C25H26ClN5O3/c1-15-11-18(31-7-9-34-10-8-31)13-20-23(15)30-24(2
9-20)22-19(5-6-27-25(22)33)28-14-21(32)16-3-2-4-17(26)12-16/h2-6,
11-13,21,28-30,32H,7-10,14H2,1H3/b24-22-/t21-/m1/s1
InChIKeyUGQMURPIMYALPH-KKPVDXMRSA-N
Canonical SMILESCC1=CC(=CC2=C1NC(=C3C(=CC=NC3=O)NCC(C4=CC(=CC=C4)Cl)O)N2)N5CCOCC5    
Isomeric SMILESCC1=CC(=CC2=C1N/C(=C\3/C(=CC=NC3=O)NC[C@H](C4=CC(=CC=C4)Cl)O)/N2)
N5CCOCC5
TargetCyclin-dependent kinase 2Inhibitor[1]
Cytochrome P450 3A4Inhibitor[2]
Focal adhesion kinase 1Inhibitor[1]
G1/S-specific cyclin E2Inhibitor[1]
Hepatocyte growth factor receptorInhibitor[1]
Insulin-like growth factor I receptorInhibitor[3]
MAP kinase ERK2Inhibitor[1]
Platelet-derived growth factor receptor alpha Inhibitor[1]
Platelet-derived growth factor receptor betaInhibitor[1]
Receptor protein-tyrosine kinase erbB-2Inhibitor[1]
Serine/threonine-protein kinase AKTInhibitor[1]
Tyrosine-protein kinase LCKInhibitor[1]
Vascular endothelial growth factor receptor 2Inhibitor[1]
Ref 1J Med Chem. 2005 Sep 8;48(18):5639-43.Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity. To Reference
Ref 2J Med Chem. 2008 Oct 9;51(19):5897-900. Epub 2008 Sep 3.Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an orally efficacious inhibitor of insulin-like growth factor-1 receptor kinase with broad spectrum in vivo antitumor activity. To Reference
Ref 3Bioorg Med Chem Lett. 2010 Mar 1;20(5):1744-8. Epub 2010 Jan 21.SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors. To Reference



 

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