Therapeutic Targets Database
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TTD Drug ID: DNC006038

Drug Information
NameTPA-023
IndicationNot AvailableExperimental    
Structure

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InChI1S/C20H22FN7O/c1-5-27-17(22-12-23-27)11-29-19-14(20(2,3)4)10-16-2
4-25-18(28(16)26-19)13-8-6-7-9-15(13)21/h6-10,12H,5,11H2,1-4H3
InChIKeyQKIWQBLNTSQOLY-UHFFFAOYSA-N
Canonical SMILESCCN1C(=NC=N1)COC2=NN3C(=NN=C3C4=CC=CC=C4F)C=C2C(C)(C)C    
TargetGABA receptor alpha-1 subunitInhibitor[1]
GABA receptor alpha-2 subunitInhibitor[1]
GABA receptor alpha-3 subunitInhibitor[1]
GABA receptor alpha-5 subunitInhibitor[2]
GABA receptor beta-3 subunitInhibitor[1]
GABA receptor gamma-2 subunitInhibitor[1]
Ref 1J Med Chem. 2005 Nov 17;48(23):7089-92.7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine: a functionally selective gamma-aminobutyric acid(A) (GABA(A)) alpha2/alpha3-subtype selective agonist that exhibits potent anxiolytic activity but is not sedating in animal models. To Reference
Ref 2J Med Chem. 2006 Jan 12;49(1):35-8.Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABA(A)alpha2/alpha3 binding site agonists for the treatment of anxiety disorders. To Reference



 

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