Therapeutic Targets Database
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TTD Drug ID: DNC006213

Drug Information
NameCL-387785
IndicationNot AvailableExperimental    
Structure

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InChI1S/C18H13BrN4O/c1-2-4-17(24)22-14-7-8-16-15(10-14)18(21-11-20-16)
23-13-6-3-5-12(19)9-13/h3,5-11H,1H3,(H,22,24)(H,20,21,23)
InChIKeyBTYYWOYVBXILOJ-UHFFFAOYSA-N
Canonical SMILESCC#CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)Br    
TargetEpidermal growth factor receptor erbB1Inhibitor[1]
Receptor protein-tyrosine kinase erbB-2Inhibitor[2]
Receptor protein-tyrosine kinase erbB-4Inhibitor[2]
Ref 1J Med Chem. 2009 Feb 26;52(4):964-75.Computational studies of epidermal growth factor receptor: docking reliability, three-dimensional quantitative structure-activity relationship analysis, and virtual screening studies. To Reference
Ref 2J Med Chem. 2006 Feb 23;49(4):1475-85.Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors. To Reference



 

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