Therapeutic Targets Database
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TTD Drug ID: DNC006358

Drug Information
NameGW-788388
IndicationNot AvailableExperimental    
Structure

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InChI1S/C25H23N5O2/c31-25(29-20-9-13-32-14-10-20)18-6-4-17(5-7-18)23-1
5-19(8-12-27-23)21-16-28-30-24(21)22-3-1-2-11-26-22/h1-8,11-12,15
-16,20H,9-10,13-14H2,(H,28,30)(H,29,31)
InChIKeySAGZIBJAQGBRQA-UHFFFAOYSA-N
Canonical SMILESC1COCCC1NC(=O)C2=CC=C(C=C2)C3=NC=CC(=C3)C4=C(NN=C4)C5=CC=CC=N5    
TargetMAP kinase p38 alphaInhibitor[1]
TGF-beta receptor type IInhibitor[1]
Tyrosine-protein kinase LCKInhibitor[1]
Ref 1J Med Chem. 2006 Apr 6;49(7):2210-21.Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): a potent, selective, and orally active transforming growth factor-beta type I receptor inhibitor. To Reference



 

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