Therapeutic Targets Database
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TTD Drug ID: DNC006594

Drug Information
NameAG1295
SynonymsAG1295
IndicationNot AvailableExperimental    
Structure

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InChI1S/C16H14N2/c1-11-8-14-15(9-12(11)2)18-16(10-17-14)13-6-4-3-5-7-1
3/h3-10H,1-2H3
InChIKeyFQNCLVJEQCJWSU-UHFFFAOYSA-N
Canonical SMILESCC1=CC2=NC=C(N=C2C=C1C)C3=CC=CC=C3    
TargetPlatelet-derived growth factor receptor alpha Inhibitor[1]
Platelet-derived growth factor receptor betaInhibitor[2]
Tyrosine-protein kinase receptor FLT3Inhibitor[2]
Vascular endothelial growth factor receptor 2Inhibitor[3]
Ref 1J Med Chem. 2006 Jun 1;49(11):3101-15.Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. To Reference
Ref 2Bioorg Med Chem. 2007 Mar 1;15(5):2187-97. Epub 2006 Dec 12.Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones. To Reference
Ref 3Bioorg Med Chem. 2009 Oct 15;17(20):7324-36. Epub 2009 Aug 22.Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors. To Reference



 

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