Therapeutic Targets Database
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TTD Drug ID: DNC006871

Drug Information
NamePD-0173955;PD-17395
IndicationNot AvailableExperimental    
Structure

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InChI1S/C21H16Cl2N4OS/c1-27-19-12(9-15(20(27)28)18-16(22)7-4-8-17(18)2
3)11-24-21(26-19)25-13-5-3-6-14(10-13)29-2/h3-11H,1-2H3,(H,24,25,
26)
InChIKeyVAARYSWULJUGST-UHFFFAOYSA-N
Canonical SMILESCN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=CC=C3Cl)Cl)NC4=CC(=CC=C4)SC    
TargetFibroblast growth factor receptor 1Inhibitor[1]
Platelet-derived growth factor receptor alpha Inhibitor[1]
Platelet-derived growth factor receptor betaInhibitor[1]
Tyrosine-protein kinase ABLInhibitor[2]
Tyrosine-protein kinase LCKInhibitor[1]
Tyrosine-protein kinase SRCInhibitor[1]
Ref 1Biochem Pharmacol. 2000 Oct 1;60(7):885-98.Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. To Reference
Ref 2J Med Chem. 2006 Sep 21;49(19):5759-68.Structural insights into the ATP binding pocket of the anaplastic lymphoma kinase by site-directed mutagenesis, inhibitor binding analysis, and homology modeling. To Reference



 

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