Therapeutic Targets Database
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TTD Drug ID: DNC006887

Drug Information
NameHoo-Phe-Orn-Pro-hle-Pff-Phe-NH2
IndicationNot AvailableExperimental    
Structure

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InChI1S/C49H63FN10O9/c1-29(2)17-22-34(43(63)56-38(27-32-18-20-33(50)21
-19-32)45(65)55-36(42(52)62)25-30-11-5-3-6-12-30)53-47(67)40-16-1
0-24-60(40)48(68)35(15-9-23-51)54-44(64)37(26-31-13-7-4-8-14-31)5
7-46(66)39-28-41(61)59-49(69)58-39/h3-8,11-14,18-21,29,34-40H,9-1
0,15-17,22-28,51H2,1-2H3,(H2,52,62)(H,53,67)(H,54,64)(H,55,65)(H,
56,63)(H,57,66)(H2,58,59,61,69)/t34-,35-,36+,37-,38-,39-,40?/m0/s
1
InChIKeyHXKFHHNEFCZKPG-XRBZTNMESA-N
Canonical SMILESCC(C)CCC(C(=O)NC(CC1=CC=C(C=C1)F)C(=O)NC(CC2=CC=CC=C2)C(=O)N)NC(=O)
C3CCCN3C(=O)C(CCCN)NC(=O)C(CC4=CC=CC=C4)NC(=O)C5CC(=O)NC(=O)N5    
Isomeric SMILESCC(C)CC[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)F)C(=O)N[C@H](CC2=CC=CC=C2)C(=
O)N)NC(=O)C3CCCN3C(=O)[C@H](CCCN)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@@H]
5CC(=O)NC(=O)N5
TargetMelanocortin receptor 4Inhibitor[1]
Neurokinin 2 receptorInhibitor[1]
Vasopressin V1a receptorInhibitor[1]
Ref 1Bioorg Med Chem Lett. 2006 Oct 1;16(19):5088-92. Epub 2006 Jul 28.Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: increased receptor specificity and in vivo activity. To Reference



 

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