Therapeutic Targets Database
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TTD Drug ID: DNC006900

Drug Information
NameCURCUMIN
SynonymsCURCUMIN
IndicationNot AvailableExperimental    
Structure

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InChI1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15
-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3
InChIKeyVFLDPWHFBUODDF-UHFFFAOYSA-N
Canonical SMILESCOC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O    
TargetBeta amyloid A4 proteinInhibitor[1]
Carbonic anhydrase 15Inhibitor[2]
Carbonic anhydrase IInhibitor[2]
Carbonic anhydrase IIInhibitor[2]
Carbonic anhydrase IVInhibitor[2]
Carbonic anhydrase IXInhibitor[2]
Carbonic anhydrase VIInhibitor[2]
Carbonic anhydrase XIIInhibitor[2]
Carbonic anhydrase XIVInhibitor[2]
Cyclooxygenase-1Inhibitor[3]
Cyclooxygenase-2Inhibitor[3]
Cytochrome P450 3A4Inhibitor[4]
DNA (cytosine-5)-methyltransferase 1Inhibitor[5]
DNA (cytosine-5)-methyltransferase 3BInhibitor[5]
Matrix metalloproteinase 13Inhibitor[6]
Matrix metalloproteinase 9Inhibitor[7]
Nitric oxide synthase, inducibleInhibitor[8]
Xanthine dehydrogenaseInhibitor[9]
Ref 1J Med Chem. 2006 Oct 5;49(20):6111-9.Curcumin and dehydrozingerone derivatives: synthesis, radiolabeling, and evaluation for beta-amyloid plaque imaging. To Reference
Ref 2Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. Epub 2010 Jul 13.Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. To Reference
Ref 3Bioorg Med Chem Lett. 2005 Apr 1;15(7):1793-7.Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammatory agents. To Reference
Ref 4Eur J Med Chem. 2008 Aug;43(8):1621-31. Epub 2007 Nov 17.Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues. To Reference
Ref 5Bioorg Med Chem. 2010 Jan 15;18(2):822-9. Epub 2009 Nov 27.Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. To Reference
Ref 6Bioorg Med Chem. 2009 Feb 1;17(3):990-1005. Epub 2008 Mar 6.High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate. To Reference
Ref 7Bioorg Med Chem. 2009 Feb 1;17(3):1290-6. Epub 2009 Jan 6.Synthesis and biological evaluation of curcuminoid pyrazoles as new therapeutic agents in inflammatory bowel disease: effect on matrix metalloproteinases. To Reference
Ref 8Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. Epub 2007 Dec 11.A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. To Reference
Ref 9J Nat Prod. 2009 Apr;72(4):725-31.Inhibition studies of bovine xanthine oxidase by luteolin, silibinin, quercetin, and curcumin. To Reference



 

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