Therapeutic Targets Database
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TTD Drug ID: DNC007005

Drug Information
NameBISINDOLYLMALEIMIDE IX
SynonymsBISINDOLYLMALEIMIDE IX
IndicationNot AvailableExperimental    
Structure

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InChI1S/C25H23N5O2S/c1-29-13-17(15-7-2-4-9-19(15)29)21-22(24(32)28-23(
21)31)18-14-30(11-6-12-33-25(26)27)20-10-5-3-8-16(18)20/h2-5,7-10
,13-14H,6,11-12H2,1H3,(H3,26,27)(H,28,31,32)
InChIKeyDSXXEELGXBCYNQ-UHFFFAOYSA-N
Canonical SMILESCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCSC(=N)N    
TargetGlycogen synthase kinase-3 betaInhibitor[1]
MAP kinase ERK2Inhibitor[1]
MAP kinase p38 alphaInhibitor[1]
MAP kinase p38 betaInhibitor[1]
MAP kinase p38 gammaInhibitor[1]
NAD-dependent deacetylase sirtuin 1Inhibitor[2]
Protein kinase C alpha Inhibitor[1]
Rho-associated protein kinase 2Inhibitor[1]
Ribosomal protein S6 kinase alpha 5Inhibitor[1]
Serine/threonine-protein kinase AKTInhibitor[1]
Tyrosine-protein kinase LCKInhibitor[1]
c-Jun N-terminal kinase 1Inhibitor[1]
Ref 1Biochem J. 2000 Oct 1;351(Pt 1):95-105.Specificity and mechanism of action of some commonly used protein kinase inhibitors. To Reference
Ref 2J Med Chem. 2006 Dec 14;49(25):7307-16.Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition. To Reference



 

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