Therapeutic Targets Database
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TTD Drug ID: DNC007144

Drug Information
NameBAICALEIN
SynonymsBAICALEIN
IndicationNot AvailableExperimental    
Structure

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InChI1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13
(9)12/h1-7,17-19H
InChIKeyFXNFHKRTJBSTCS-UHFFFAOYSA-N
Canonical SMILESC1=CC=C(C=C1)C2=CC(=O)C3=C(C(=C(C=C3O2)O)O)O    
TargetArachidonate 5-lipoxygenaseInhibitor[1]
Glyoxalase IInhibitor[2]
Leukocyte adhesion molecule-1Inhibitor[3]
P-selectinInhibitor[3]
Prolyl endopeptidaseInhibitor[4]
TNF-alphaInhibitor[5]
Xanthine dehydrogenaseInhibitor[6]
Ref 1J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. To Reference
Ref 2Bioorg Med Chem. 2008 Apr 1;16(7):3969-75. Epub 2008 Jan 24.Structure-activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects. To Reference
Ref 3J Med Chem. 2007 Mar 22;50(6):1101-15. Epub 2007 Feb 16.Rational design of novel, potent small molecule pan-selectin antagonists. To Reference
Ref 4Bioorg Med Chem. 2008 Aug 1;16(15):7516-24. Epub 2008 Apr 29.Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. To Reference
Ref 5Bioorg Med Chem Lett. 2010 Nov 1;20(21):6195-8. Epub 2010 Sep 16.Discovery of the inhibitors of tumor necrosis factor alpha with structure-based virtual screening. To Reference
Ref 6J. Nat. Prod. 51(2):345-348 (1988) To Reference



 

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