Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DNC007402

Drug Information
NameR-226161
IndicationNot AvailableExperimental    
Structure

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InChI1S/C27H32FN3O4/c1-18(12-19-4-6-20(28)7-5-19)15-30-8-10-31(11-9-30
)16-26-22-17-34-23-14-25(33-3)24(32-2)13-21(23)27(22)29-35-26/h4-
7,12-14,22,26H,8-11,15-17H2,1-3H3/b18-12+/t22-,26-/m0/s1
InChIKeyUCNOTTVNPRSTFW-XSFNXXSESA-N
Canonical SMILESCC(=CC1=CC=C(C=C1)F)CN2CCN(CC2)CC3C4COC5=CC(=C(C=C5C4=NO3)OC)OC    
Isomeric SMILESC/C(=C\C1=CC=C(C=C1)F)/CN2CCN(CC2)C[C@H]3[C@@H]4COC5=CC(=C(C=C5C4=NO3)
OC)OC
TargetAlpha-1a adrenergic receptorInhibitor[1]
Alpha-2a adrenergic receptorInhibitor[1]
Alpha-2b adrenergic receptorInhibitor[1]
Alpha-2c adrenergic receptorInhibitor[1]
Dopamine D3 receptorInhibitor[1]
Dopamine transporterInhibitor[1]
Histamine H1 receptorInhibitor[1]
Neurokinin 1 receptorInhibitor[1]
Serotonin transporterInhibitor[1]
Ref 1Bioorg Med Chem. 2007 Jun 1;15(11):3649-60. Epub 2007 Mar 21.Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-adrenoceptor antagonism. To Reference



 

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