Therapeutic Targets Database
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TTD Drug ID: DNC007478

Drug Information
NameKNI-10006
IndicationNot AvailableExperimental    
Structure

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InChI1S/C35H41N3O6S/c1-21-11-10-12-22(2)31(21)44-19-28(40)36-26(17-23-
13-6-5-7-14-23)30(41)34(43)38-20-45-35(3,4)32(38)33(42)37-29-25-1
6-9-8-15-24(25)18-27(29)39/h5-16,26-27,29-30,32,39,41H,17-20H2,1-
4H3,(H,36,40)(H,37,42)/t26-,27+,29-,30-,32+/m0/s1
InChIKeyKKTYZYHUPKXLPL-RIQJEONASA-N
Canonical SMILESCC1=C(C(=CC=C1)C)OCC(=O)NC(CC2=CC=CC=C2)C(C(=O)N3CSC(C3C(=O)NC4C(CC5=CC=
CC=C45)O)(C)C)O    
Isomeric SMILESCC1=C(C(=CC=C1)C)OCC(=O)N[C@@H](CC2=CC=CC=C2)[C@@H](C(=O)N3CSC([C@H]3C(=
O)N[C@@H]4[C@@H](CC5=CC=CC=C45)O)(C)C)O
TargetCathepsin DInhibitor[1]
Plasmepsin 1Inhibitor[1]
Plasmepsin 2Inhibitor[2]
Ref 1Bioorg Med Chem. 2009 Aug 15;17(16):5933-49. Epub 2009 Jul 3.alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases. To Reference
Ref 2Bioorg Med Chem Lett. 2010 Aug 15;20(16):4836-9. Epub 2010 Jun 25.Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution. To Reference



 

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