Therapeutic Targets Database
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TTD Drug ID: DNC007524

Drug Information
Name(S)-1-(1H-indazol-4-yl)-3-(1-p-tolylethyl)urea
IndicationNot AvailableExperimental    
Structure

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InChI1S/C17H18N4O/c1-11-6-8-13(9-7-11)12(2)19-17(22)20-15-4-3-5-16-14(
15)10-18-21-16/h3-10,12H,1-2H3,(H,18,21)(H2,19,20,22)/t12-/m0/s1
InChIKeySHOUDGQMQHLAFL-LBPRGKRZSA-N
Canonical SMILESCC1=CC=C(C=C1)C(C)NC(=O)NC2=CC=CC3=C2C=NN3    
Isomeric SMILESCC1=CC=C(C=C1)[C@H](C)NC(=O)NC2=CC=CC3=C2C=NN3
TargetVanilloid receptorInhibitor[1]
Ref 1Bioorg Med Chem Lett. 2007 Jul 15;17(14):3894-9. Epub 2007 May 3.Alpha-methylation at benzylic fragment of N-aryl-N'-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model. To Reference



 

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