Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DNC007741

Drug Information
NameLOMERIZINE
SynonymsLOMERIZINE
IndicationNot AvailableExperimental    
Structure

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InChI1S/C27H30F2N2O3/c1-32-24-13-8-21(26(33-2)27(24)34-3)18-30-14-16-3
1(17-15-30)25(19-4-9-22(28)10-5-19)20-6-11-23(29)12-7-20/h4-13,25
H,14-18H2,1-3H3
InChIKeyJQSAYKKFZOSZGJ-UHFFFAOYSA-N
Canonical SMILESCOC1=C(C(=C(C=C1)CN2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)OC)OC    
CAS NumberCAS 101477-55-8
TargetSodium channel protein type V alpha subunitInhibitor[1]
Sodium channel protein type VI alpha subunit Inhibitor[1]
Voltage-gated N-type calcium channel alpha-1B subunitInhibitor[2]
Ref 1J Med Chem. 2001 Jan 18;44(2):115-37.Medicinal chemistry of neuronal voltage-gated sodium channel blockers. To Reference
Ref 2Bioorg Med Chem Lett. 2007 Feb 1;17(3):662-7. Epub 2006 Nov 6.Synthesis and SAR of novel 2-arylthiazolidinones as selective analgesic N-type calcium channel blockers. To Reference



 

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