Therapeutic Targets Database
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TTD Drug ID: DNC007764

Drug Information
Name(Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-one
IndicationNot AvailableExperimental    
Structure

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InChI1S/C13H10N2O/c16-13-11(8-9-4-3-7-14-9)10-5-1-2-6-12(10)15-13/h1-8
,14H,(H,15,16)/b11-8-
InChIKeySEZFNTZQMWJIAI-FLIBITNWSA-N
Canonical SMILESC1=CC=C2C(=C1)C(=CC3=CC=CN3)C(=O)N2    
Isomeric SMILESC1=CC=C2C(=C1)/C(=C/C3=CC=CN3)/C(=O)N2
Target3-phosphoinositide dependent protein kinase-1Inhibitor[1]
Serine/threonine-protein kinase AKTInhibitor[1]
Tyrosine-protein kinase receptor RETInhibitor[2]
Ref 1Bioorg Med Chem Lett. 2007 Jul 15;17(14):3814-8. Epub 2007 Apr 27.Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity. To Reference
Ref 2Bioorg Med Chem. 2010 Feb 15;18(4):1482-96. Epub 2010 Jan 11.Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors. To Reference



 

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