Therapeutic Targets Database
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TTD Drug ID: DNC008071

Drug Information
Name9-N-ETHYL-8-ETHOXY-MANZAMINE A
Synonyms9-N-ETHYL-8-ETHOXY-MANZAMINE A
IndicationNot AvailableExperimental    
Structure

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InChI1S/C40H52N4O2/c1-3-43-36-30(17-15-18-34(36)46-4-2)31-19-22-41-35(
37(31)43)32-27-40(45)21-12-8-5-6-9-13-23-42-25-20-33(32)39(28-42)
26-29-16-11-7-10-14-24-44(29)38(39)40/h5,8,11,15-19,22,27,29,33,3
8,45H,3-4,6-7,9-10,12-14,20-21,23-26,28H2,1-2H3/b8-5-,16-11-/t29-
,33?,38+,39-,40-/m0/s1
InChIKeyZOZMQOQRAXCUJA-OGIDAHSQSA-N
Canonical SMILESCCN1C2=C(C=CC=C2OCC)C3=C1C(=NC=C3)C4=CC5(CCC=CCCCCN6CCC4C7(C6)C5N8CCCCC=
CC8C7)O    
Isomeric SMILESCCN1C2=C(C=CC=C2OCC)C3=C1C(=NC=C3)C4=C[C@]5(CC/C=C\CCCCN6CCC4[C@]7(C6)
[C@H]5N8CCCC/C=C\[C@H]8C7)O
TargetGlycogen synthase kinase-3 betaInhibitor[1]
Ref 1J Nat Prod. 2007 Sep;70(9):1397-405. Epub 2007 Aug 21.Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease. To Reference



 

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