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TTD Drug ID:
DNC008074
Drug
Information |
Name | 6-hydroxymanzamine A | Indication | Not Available | Experimental | Structure |
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| InChI | 1S/C36H44N4O2/c41-26-12-13-31-28(21-26)27-14-17-37-32(33(27)38-31 )29-23-36(42)16-8-4-1-2-5-9-18-39-20-15-30(29)35(24-39)22-25-11-7 -3-6-10-19-40(25)34(35)36/h1,4,7,11-14,17,21,23,25,30,34,38,41-42 H,2-3,5-6,8-10,15-16,18-20,22,24H2/b4-1-,11-7-/t25-,30?,34+,35-,3 6-/m0/s1 | InChIKey | CANRNZBVKKQKEQ-DIFNJBIASA-N | Canonical SMILES | C1CCN2CCC3C(=CC(CCC=CC1)(C4C3(C2)CC5N4CCCCC=C5)O)C6=NC=CC7=C6NC8=C7C=C (C=C8)O | Isomeric SMILES | C1CCN2CCC3C(=C[C@@](CC/C=C\C1)([C@H]4[C@]3(C2)C[C@H]/5N4CCCC/C=C5)O)C6= NC=CC7=C6NC8=C7C=C(C=C8)O | Target | Glycogen synthase kinase-3 beta |  | Inhibitor | [1] | Ref 1 | J Nat Prod. 2007 Sep;70(9):1397-405. Epub 2007 Aug 21.Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease. To Reference |
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