Therapeutic Targets Database
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TTD Drug ID: DNC008115

Drug Information
NameKN-62
IndicationNot AvailableExperimental    
Structure

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InChI1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)
35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-
14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,3
5H,21-25H2,1H3/t35-/m0/s1
InChIKeyRJVLFQBBRSMWHX-DHUJRADRSA-N
Canonical SMILESCN(C(CC1=CC=C(C=C1)OS(=O)(=O)C2=CC=CC3=C2C=CN=C3)C(=O)N4CCN(CC4)C5=CC=
CC=C5)S(=O)(=O)C6=CC=CC7=C6C=CN=C7    
Isomeric SMILESCN([C@@H](CC1=CC=C(C=C1)OS(=O)(=O)C2=CC=CC3=C2C=CN=C3)C(=O)N4CCN(CC4)C5=
CC=CC=C5)S(=O)(=O)C6=CC=CC7=C6C=CN=C7
TargetMAP kinase ERK2Inhibitor[1]
MAP kinase p38 alphaInhibitor[1]
MAP kinase p38 betaInhibitor[1]
MAP kinase p38 gammaInhibitor[1]
P2X purinoceptor 7Inhibitor[2]
Protein kinase C alpha Inhibitor[1]
Rho-associated protein kinase 2Inhibitor[1]
Ribosomal protein S6 kinase alpha 5Inhibitor[1]
Serine/threonine-protein kinase AKTInhibitor[1]
Serine/threonine-protein kinase Chk1 Inhibitor[1]
Serine/threonine-protein kinase Sgk1Inhibitor[1]
Tyrosine-protein kinase LCKInhibitor[1]
c-Jun N-terminal kinase 1Inhibitor[1]
Ref 1Biochem J. 2000 Oct 1;351(Pt 1):95-105.Specificity and mechanism of action of some commonly used protein kinase inhibitors. To Reference
Ref 2Bioorg Med Chem Lett. 2009 Nov 1;19(21):6053-8. Epub 2009 Sep 17.Synthesis and structure-activity relationships of pyrazolodiazepine derivatives as human P2X7 receptor antagonists. To Reference



 

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