Therapeutic Targets Database
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TTD Drug ID: DNC008342

Drug Information
NameBIRB796
SynonymsBIRB796
IndicationNot AvailableExperimental    
Structure

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InChI1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)3
3-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-1
9-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
InChIKeyMVCOAUNKQVWQHZ-UHFFFAOYSA-N
Canonical SMILESCC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)
OCCN5CCOCC5    
TargetHeat shock protein beta-1Inhibitor[1]
MAP kinase p38 alphaInhibitor[2]
MAP kinase p38 betaInhibitor[3]
MAP kinase p38 gammaInhibitor[3]
Serine/threonine-protein kinase B-rafInhibitor[2]
Serine/threonine-protein kinase RAFInhibitor[3]
Tyrosine-protein kinase LCKInhibitor[3]
c-Jun N-terminal kinase 2Inhibitor[3]
Ref 1Bioorg Med Chem Lett. 2008 Aug 1;18(15):4433-7. Epub 2008 Jun 12.Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes. To Reference
Ref 2Bioorg Med Chem. 2010 Aug 1;18(15):5738-48. Epub 2010 Jun 4.The design, synthesis, and evaluation of 8 hybrid DFG-out allosteric kinase inhibitors: a structural analysis of the binding interactions of Gleevec, Nexavar, and BIRB-796. To Reference
Ref 3J Med Chem. 2008 Jul 24;51(14):4122-49. Epub 2008 Jun 26.Design, synthesis, and biological evaluation of novel Tri- and tetrasubstituted imidazoles as highly potent and specific ATP-mimetic inhibitors of p38 MAP kinase: focus on optimized interactions with the enzyme's surface-exposed front region. To Reference



 

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