Therapeutic Targets Database
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TTD Drug ID: DNC008527

Drug Information
Name8-chloro-quinoline-3-carbonitrile
IndicationNot AvailableExperimental    
Structure

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InChI1S/C20H13Cl2FN6/c21-16-4-12(1-2-18(16)23)29-19-11(6-24)7-27-20-15
(19)3-13(5-17(20)22)26-9-14-8-25-10-28-14/h1-5,7-8,10,26H,9H2,(H,
25,28)(H,27,29)
InChIKeyONXROKMQGCSOMG-UHFFFAOYSA-N
Canonical SMILESC1=CC(=C(C=C1NC2=C(C=NC3=C(C=C(C=C32)NCC4=CN=CN4)Cl)C#N)Cl)F    
TargetMatrix metalloproteinase 3Inhibitor[1]
Mitogen-activated protein kinase kinase kinase 8Inhibitor[1]
Ref 1J Biol Chem. 2007 Nov 16;282(46):33295-304. Epub 2007 Sep 11.Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood. To Reference



 

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