Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DNC008950

Drug Information
NameGSK-690693
IndicationNot AvailableExperimental    
Structure

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InChI1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-
21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9
-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1
InChIKeyKGPGFQWBCSZGEL-ZDUSSCGKSA-N
Canonical SMILESCCN1C2=C(C(=NC=C2OCC3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N    
Isomeric SMILESCCN1C2=C(C(=NC=C2OC[C@H]3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N
TargetAMP-activated protein kinase, alpha-2 subunitInhibitor[1]
Glycogen synthase kinase-3 betaInhibitor[2]
Protein kinase C betaInhibitor[1]
Protein kinase C deltaInhibitor[1]
Protein kinase C epsilonInhibitor[1]
Protein kinase C etaInhibitor[1]
Protein kinase C thetaInhibitor[1]
Rho-associated protein kinase 1 Inhibitor[1]
Serine/threonine-protein kinase AKTInhibitor[1]
Serine/threonine-protein kinase AKT3Inhibitor[1]
cGMP-dependent protein kinase 1 betaInhibitor[1]
Ref 1J Med Chem. 2008 Sep 25;51(18):5663-79.Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. To Reference
Ref 2Bioorg Med Chem Lett. 2009 Mar 1;19(5):1508-11. Epub 2009 Jan 9.Aminofurazans as potent inhibitors of AKT kinase. To Reference



 

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