Therapeutic Targets Database
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TTD Drug ID: DNC009909

Drug Information
NamePD-0173956
IndicationNot AvailableExperimental    
Structure

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InChI1S/C20H13Cl2FN4O/c1-27-18-11(9-14(19(27)28)17-15(21)3-2-4-16(17)2
2)10-24-20(26-18)25-13-7-5-12(23)6-8-13/h2-10H,1H3,(H,24,25,26)
InChIKeyZSHRAUSJZQDIJR-UHFFFAOYSA-N
Canonical SMILESCN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=CC=C3Cl)Cl)NC4=CC=C(C=C4)F    
TargetEpidermal growth factor receptor erbB1Inhibitor[1]
Fibroblast growth factor receptor 1Inhibitor[1]
MAP kinase p38 alphaInhibitor[2]
Platelet-derived growth factor receptor alpha Inhibitor[1]
Platelet-derived growth factor receptor betaInhibitor[1]
Stem cell growth factor receptorInhibitor[2]
Tyrosine-protein kinase ABLInhibitor[2]
Tyrosine-protein kinase LCKInhibitor[1]
Tyrosine-protein kinase SRCInhibitor[2]
Ref 1Biochem Pharmacol. 2000 Oct 1;60(7):885-98.Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. To Reference
Ref 2Bioorg Med Chem Lett. 2009 Dec 15;19(24):6872-6. Epub 2009 Oct 23.Structure-activity relationships of 6-(2,6-dichlorophenyl)-8-methyl-2-(phenylamino)pyrido[2,3-d]pyrimidin-7-ones: toward selective Abl inhibitors. To Reference



 

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